Find answers to the most common questions about NavDx\u00ae testing. If you don’t see the answer you need, reach out to us.<\/p>\n[\/nectar_responsive_text][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”100px” equal_height=”yes” content_placement=”middle” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#FFFFFF” scene_position=”center” top_padding=”6%” bottom_padding=”7%” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” row_position_desktop=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” flex_gap_desktop=”10px” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][nectar_responsive_text inherited_font_style=”default” text_color=”#25476A” text_direction=”default”]What can the NavDx\u00ae test tell my Provider and me?
\nNavDx testing is currently being used to help Providers detect and monitor HPV+ head & neck and anal cancer. NavDx testing can provide more information than your physician can get from physical exams and imaging alone. Some of the questions NavDx testing can answer include:<\/p>\n
Is my cancer due to HPV?
\nHas my treatment worked and is my cancer gone?
\nHas my cancer returned (even if I do not have symptoms and my imaging is clear)?<\/p>\n
<\/p>\n
Will the NavDx test tell me which type of HPV I have?
\nYes. NavDx testing can detect and identify the most prevalent high-risk HPV genotypes, including HPV-16, HPV-18,
\nHPV-31, HPV-33, and HPV-35. The specific HPV genotype associated with your cancer will be included in the test report that goes to your Provider.<\/p>\n
<\/p>\n
Who is appropriate for NavDx testing?
\nAny patient diagnosed with HPV+ head & neck cancer or HPV+ anal cancer may benefit from NavDx testing. With a simple blood draw, a NavDx test can detect whether HPV+ cancer is present in your body. By repeating the test over time, your Provider can see how well your treatment is working and whether your cancer has returned. Routine NavDx testing can detect cancer recurrence before it produces symptoms. Studies show that the test can detect HPV+ head & neck cancer a median of 4 months earlier than it can be seen on imaging 6 and HPV+ anal cancer a median of 59 days earlier than it can be seen on imaging.4<\/p>\n
<\/p>\n
How can the NavDx test be used to help personalize my HPV+ cancer care?
\nNavDx testing can detect the presence of HPV+ cancer throughout your care journey. Before you start treatment, a NavDx test may be used to confirm the type of HPV associated with your cancer. The test also analyzes the amount of TTMV\u00ae-HPV DNA in your blood, to establish your TTMV Score. During your treatment, the test can be repeated to assess if the tumor is responding to treatment. Once your treatment has been completed, the test can determine whether any of the cancer is still in your body. Once you are in follow-up for recurrence monitoring, the test is repeated regularly as ordered by your Provider, to give you early warning if the cancer returns.<\/p>\n
<\/p>\n
How often should I have a NavDx test?
\nWhen and how often you should be monitored with the NavDx test is up to you and your Provider.<\/p>\n
If you are covered by Medicare, CMS coverage policy for recurrence monitoring allows NavDx testing at the following intervals:<\/p>\n
HPV+ head & neck cancer:
\n4 tests per year in year 1 and 2 post-treatment
\n2 tests per year in years 3, 4, and 5 post-treatment<\/p>\n
HPV+ anal cancer
\n4 tests per year in years 1, 2, and 3 post-treatment
\n2 tests per year in years 4 and 5 post-treatment<\/p>\n
<\/p>\n
<\/p>\n
What are my options regarding where to get my blood drawn?
\nThe NavDx test only requires a simple blood draw, which needs no special preparation on the patient\u2019s part. The blood draw can be performed at your Provider\u2019s facility, or you can use Naveris\u00ae-arranged Phlebotomy to have your blood draw completed at a walk-in clinic near you or at another convenient location, such as your home or workplace. Contact our Patient Navigation Team at support@naveris.com or (833) 628-3747 with questions or to set up Naveris-arranged Phlebotomy. Learn More \u2192 [link to NAP brochure]\n
<\/p>\n
Do I need to fast or prepare in any special way before my blood draw?
\nNo special preparation is required. You may eat and drink normally before your NavDx blood draw. If you have questions about your blood draw appointment, contact the location where your draw will take place or contact our Patient Navigation Team at support@naveris.com or (833) 628-3747.<\/p>\n
<\/p>\n
Can the NavDx test be used along with imaging scans to help monitor for cancer recurrence?
\nYes, your Provider can use a combination of NavDx testing and imaging scans to monitor for cancer recurrence. Even with successful treatment, 15% to 25% of people with HPV+ head & neck cancer and 20% to 30% of people with HPV+ anal cancer have a recurrence within 5 years.11,12 Regular NavDx testing can help detect head & neck cancer recurrence a median of 4 months earlier than it can be found through imaging and anal cancer recurrence a median of 59 days earlier than it can be found through imaging.4,6<\/p>\n
<\/p>\n
Does the NavDx test replace my imaging scans?
\nNo. NavDx testing is designed to complement, not replace, imaging and clinical examinations. Your Provider may use NavDx testing alongside CT scans, PET scans, or other imaging to get a more complete picture of your cancer status. The NavDx test and imaging each provide different types of information, and using both together can help your Provider make more informed decisions.<\/p>\n
<\/p>\n
How long does it take to get results?
\nNavDx results are typically available within 7 business days of your blood sample arriving at the Naveris laboratory. Your Provider will be notified through the secure Naveris Provider Portal when your results are ready.<\/p>\n
<\/p>\n
What does a positive NavDx result mean?
\nA positive result means TTMV-HPV DNA was detected in your blood, which may indicate the presence of HPV-driven cancer activity. Your Provider will recommend appropriate next steps, which may include a physical exam, imaging, or additional testing. A positive result is a signal for your care team to investigate further; it is not a cancer diagnosis.<\/p>\n
<\/p>\n
What does a negative NavDx result mean?
\nA negative result means no TTMV-HPV DNA was detected in your blood at the time of testing. In post-treatment surveillance studies, more than 98% of head & neck cancer patients and more than 92% of anal cancer patients with a negative NavDx result had no evidence of active cancer.1,2,4 Your Provider will continue monitoring you with regular NavDx testing and clinical exams according to your care plan.<\/p>\n
<\/p>\n
What does an indeterminate result mean?
\nAn indeterminate result means a small amount of TTMV-HPV DNA may have been detected, but not at a level sufficient to report as definitively positive or negative. Your Provider may recommend a physical exam, imaging, or a repeat NavDx test in a few weeks to help clarify the result. Many indeterminate results resolve with the next test. Your care team will recommend appropriate next steps. It is important not to ignore an indeterminate result.<\/p>\n
Is the NavDx test the same as the HPV test my OB\/GYN orders?
\nNo, these are different tests. Cervical HPV screening detects the presence of HPV virus in the superficial cells lining the cervix and endocervical canal. The NavDx test detects TTMV-HPV DNA, a distinct cancer biomarker released into your bloodstream by HPV-driven cancer cells.<\/p>\n
NavDx is also not used for cervical cancer screening (Pap testing). It is designed specifically to detect HPV-driven cancer in patients with HPV+ head & neck or HPV+ anal cancer.[\/nectar_responsive_text][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” equal_height=”yes” content_placement=”middle” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#25476A” scene_position=”center” top_padding=”5%” bottom_padding=”4%” text_color=”light” text_align=”center” row_border_radius=”none” row_border_radius_applies=”bg” row_position_desktop=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” flex_gap_desktop=”10px” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][nectar_responsive_text inherited_font_style=”default” text_color=”#FFFFFF” text_direction=”default”]\n
[vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” equal_height=”yes” content_placement=”bottom” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_image=”100219″ background_image_preload=”true” bg_image_type=”img” bg_position=”center center” background_image_loading=”default” bg_repeat=”no-repeat” scene_position=”center” top_padding=”7%” bottom_padding=”8%” text_color=”light” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” row_position_desktop=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” color_overlay=”#17476b” color_overlay_2=”rgba(0,21,22,0.58)” overlay_strength=”0.3″…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":48490,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-99979","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/naveris.com\/newnaveris\/index.php\/wp-json\/wp\/v2\/pages\/99979","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/naveris.com\/newnaveris\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/naveris.com\/newnaveris\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/naveris.com\/newnaveris\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/naveris.com\/newnaveris\/index.php\/wp-json\/wp\/v2\/comments?post=99979"}],"version-history":[{"count":3,"href":"https:\/\/naveris.com\/newnaveris\/index.php\/wp-json\/wp\/v2\/pages\/99979\/revisions"}],"predecessor-version":[{"id":100223,"href":"https:\/\/naveris.com\/newnaveris\/index.php\/wp-json\/wp\/v2\/pages\/99979\/revisions\/100223"}],"up":[{"embeddable":true,"href":"https:\/\/naveris.com\/newnaveris\/index.php\/wp-json\/wp\/v2\/pages\/48490"}],"wp:attachment":[{"href":"https:\/\/naveris.com\/newnaveris\/index.php\/wp-json\/wp\/v2\/media?parent=99979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}