What IS NavDx®?

NavDx is the first and only clinically validated circulating tumor-tissue–modified HPV (TTMV®) DNA blood test that aids in the detection of HPV-driven cancer.

NavDx uses proprietary technology to quantify fragments of circulating TTMV HPV DNA, a unique HPV-driven cancer biomarker that cancer cells shed into the blood. This highly accurate blood test reliably uncovers the presence of HPV+ head and neck cancer across the care continuum.¹˒²

NavDx lets you optimize clinical management of HPV-driven cancer by accurately assessing treatment response, identifying the presence of post-treatment molecular residual disease, and conveniently monitoring for recurrence.¹ The easy-to-interpret, actionable NavDx test report helps inform clinical decisions, enabling physicians to treat earlier, which may result in improved outcomes.

  • This clinical utility has been validated in a 3-year longitudinal study for head and neck cancer,¹ and proven in real-world practice⁴
  • Distinguishes TTMV HPV DNA from non-cancerous sources of HPV DNA²
  • NavDx has demonstrated 100% negative predictive value (NPV) and 94% positive predictive value (PPV) for active HPV-driven malignancy¹

This innovative and accessible blood test for HPV+ cancer helps inform clinical decisions, enabling physicians to intervene earlier, which may result in improved outcomes.¹

References: 1. Chera BS, Kumar S, Shen C, et al. Plasma circulating tumor HPV DNA for the surveillance of cancer recurrence in HPV-associated oropharyngeal cancer. J Clin Oncol. 2020;38(10):1050-1058. 2. Chera BS, Kumar S, Beaty BT, et al. Rapid clearance profile of plasma circulating tumor HPV type 16 DNA during chemoradiotherapy correlates with disease control in HPV-associated oropharyngeal cancer. Clin Cancer Res. 2019;25(15):4682-4690. 3. Head and neck cancers. Version 3.2021. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) 2021; https://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf. 4. Data on file. Naveris Inc.

To request more information or speak with your local NavDx representative, please email us at support@naveris.com, or complete the form below to get started.

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