Naveris is now CareDx. Advancing viral-mediated cancer care through precision medicine diagnostics. Read More

THE LIQUID BIOPSY TEST

Built for

HPV+ Cancer.

HPV+ Cancer Detection

with a Simple Blood Draw.

The NavDx® test is the first and most clinically validated liquid biopsy (a highly sensitive blood test) that can detect HPV+ head & neck cancer and HPV+ anal cancer, in many cases months before it shows up in clinical exams or on imaging.

HPV+ Cancer Rates Are Rising. Surveillance Has Not Adapted.

Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. Nearly all sexually active people will have at least one HPV infection in their lifetime. The good news is that most HPV infections clear on their own, and most people never even know they were infected. But a persistent infection with a high-risk strain could eventually cause cancer. Studies show that 60-70% of head & neck cancers and 90% of anal cancers are caused by HPV.11,25 Rates of both HPV+ head & neck cancer and HPV+ anal cancer have been increasing for decades.

Even with successful treatment, recurrence is a real risk:

  • Up to 25% of HPV+ head & neck cancer patients may experience recurrence12,28,29,30
  • Up to 30% of HPV+ anal cancer patients may experience recurrence33
  • Fear of recurrence is the number one concern for survivors after treatment ends,17 and this worry can negatively impact their quality of life

Post-treatment surveillance plays a critical role in catching recurrence early. For head & neck cancer patients, this typically includes physical exams, nasopharyngeal endoscopy, and imaging. For anal cancer patients, it includes physical exams, imaging, and anoscopy. These tools are valuable but limited. They may not detect disease outside the areas being examined, imaging frequently produces inconclusive results, and access to high-resolution anoscopy is severely limited across much of the United States, leaving many anal cancer patients to rely on less sensitive monitoring options.

A Liquid Biopsy Designed

for HPV+ Cancer Biology.

HPV-driven tumors shed fragments of their DNA, called TTMV-HPV DNA (tumor tissue-modified viral HPV DNA), into the bloodstream. This biomarker is specific to active HPV-driven cancer and is distinct from non-cancerous HPV DNA, making it a precise target for detection.

Standard liquid biopsy tests look for cancer-related mutations in human DNA. That approach is less effective in HPV-driven tumors, which have few mutations (low mutation burden). The NavDx test was built specifically to detect the viral DNA that is present in HPV+ cancer cells, not mutations in human DNA.

Why Do Providers and Patients Choose NavDx Testing?

Earlier Detection.

NavDx testing can detect head & neck cancer recurrence a median of 4 months earlier than imaging or physical exam,6,8 and anal cancer recurrence a median of ~2 months earlier than imaging or physical exam,4 providing an earlier window for clinical evaluation and action.

No Tissue Required.

The NavDx test can be started at any point along the care journey. NavDx testing requires only a simple blood draw. No tumor tissue. No prior genomic profile. Testing can begin before treatment, during treatment, or at any point in post-treatment surveillance.

Detection Beyond Imaging.

TTMV-HPV DNA circulates in the blood regardless of where disease may be located. NavDx testing is not limited to the areas visible on a scan or reachable by physical exam.

 

Peer-Reviewed Evidence Base.

Over 47 peer-reviewed publications from 44 unique studies, and more than 120,000 tests performed in clinical practice.

 

P R O V I D E R S

Know earlier. Act sooner.

Clinical evidence, ordering information, and the full NavDx evidence base for healthcare providers.

Explore Information for Providers
P A T I E N T S

Know more. Worry less.

What NavDx testing means for your care and how to talk to your doctor about it.

Explore Information for Patients

References

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  10. Naveris data on file.  
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