Naveris is now CareDx. Advancing viral-mediated cancer care through precision medicine diagnostics. Read More

FOR HEALTHCARE PROVIDERS TREATING HPV+ CANCER

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Performance Metrics at a Glance.

The following metrics reflect NavDx® performance across peer-reviewed published studies.

Key finding: In a large multi-institutional study (N=1,076), 97% of asymptomatic OPSCC patients with a positive NavDx result were subsequently confirmed to have recurrent disease—NavDx detected what clinical exams and imaging had not yet found.3

Explore the NavDx Test by Use Case.

Clinical evidence and performance data organized by how and when NavDx testing is used.

Surveillance

The most common use for NavDx

  • Detect recurrence earlier with high-confidence positive results
  • Provide reassurance with high-confidence negative results

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During Treatment

 

  • TTMV-HPV DNA clearance kinetics during CRT
  • Identify molecular residual disease

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Pre-Treatment

 

  • Confirm etiology of the HPV-driven cancer
  • Identify the HPV genotype of the tumor

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A pre-treatment test is not required to use the NavDx test at other points in the care journey. Monitoring with the NavDx test can be started at any time.

Expert Consensus: CHNC Recommendations.

(JCO Oncology Practice, 2025)

In December 2025, the California Head and Neck Consortium (CHNC) published the first formal expert consensus recommendations on the clinical use of ctHPVDNA testing for HPV+ oropharyngeal squamous cell carcinoma in the Journal of Clinical Oncology Oncology Practice.11 The consensus was developed using a hybrid Delphi methodology across 33 experts from 15 institutions.

Selected strong consensus statements (>80% agreement) relevant to NavDx Testing in OPSCC include:

  • ctHPVDNA assays exhibit higher specificity and sensitivity than conventional surveillance tools (87.9% agreement)
  • ctHPVDNA should supplement, not replace, conventional surveillance tools (84.8% agreement)
  • Serial, longitudinal testing should be performed, rather than one-time testing (87.9% agreement)
  • First post-treatment ctHPVDNA check should occur at 3 months (84.8% agreement)
  • The recommended testing cadence: every 3 months for years 1–2, every 6 months for years 3–5 post-treatment (87.9% agreement)
  • A single positive test should lead to immediate clinical exam and imaging (81.8% agreement)
  • If imaging is negative after a positive test, retest in 1 month (90.9% agreement)
  • Persistent post-treatment positivity warrants more intense imaging surveillance (93.9% agreement)
Access the Paper

Ready to Get Started?

Visit the Order NavDx page to place your first order, or contact our Clinical Operations Team at (833) 628-3747 or clinops@naveris.com for help setting up your practice.

References

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  10. Naveris data on file.  
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